The Old Guard are a group of mercenaries led by Andy. The character is played by Charlize Theron. They are immortals to an extent; they cannot die unless something changes and they lose this mortality. Andy, the group leader is so old she cannot recall her actual age. She has lived through several centuries and has forgotten more ways to kill than most people will learn in their entire lives. This earns her the leadership position. The narrative begins with them walking into a trap in South Sudan disguised as a hostage situation. Copley, the man who sent them into the ambush, is interested in confirming that the group is truly immortal. Copley shows this footage to Steven Merrick who is the youngest pharmacological CEO. Merrick plans to use the group as test subjects to understand the secret to their immortality. Copley’s reasons for research were out of a genuine need to help people because his wife had died and he felt that nobody else should experience such loss. Merrick’s reasons are for profiteering.

After the failed mission the team discover, via a dream, that another immortal has been created in the form of a soldier in Afghanistan. Nile died from a knife stab to her neck and woke up with no scar to the shock of all the other soldiers in the camp. She too did not know she was an immortal. Andy goes out to seek her while the rest of the team hunts for Copley. When they reconvene at an abandoned church outside Paris, the team members talk to Nile about yet another immortal member; Quynh who was captured centuries ago, placed in an iron coffin and tossed to the sea. She keeps drowning and waking up repeatedly for the last 500 years. Shortly afterwards there is an attack and two of their members are kidnapped. During this fight, Andy realizes that she has lost her immortality. They go to rescue the captured members and Nile backs out. Andy gives her the car and while she goes she realizes that Book has betrayed Andy. She goes back to find that Andy has already been captured and they discovered that she is no longer an immortal. Nile aids in their rescue and kills Merrick at the end. They reconvene and, as punishment, Book is banished for 100 years. The movie ends as a drunk Booker walks into his apartment to meet Quynh.